Lasianosides F-I: A New Iridoid and Three New Bis-Iridoid Glycosides from the Leaves of Lasianthus verticillatus (Lour.) Merr

Gadah Abdulaziz Al-Hamoud; Raha Saud Orfali; Yoshio Takeda; Sachiko Sugimoto; Yoshi Yamano; Nawal M Al Musayeib; Omer Ibrahim Fantoukh; Musarat Amina; Hideaki Otsuka; Katsuyoshi Matsunami

doi:10.3390/molecules25122798

Lasianosides F-I: A New Iridoid and Three New Bis-Iridoid Glycosides from the Leaves of Lasianthus verticillatus (Lour.) Merr

Molecules. 2020 Jun 17;25(12):2798. doi: 10.3390/molecules25122798.

Affiliations

¹ Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia.
² Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
³ Faculty of Integrated Arts and Sciences, The University of Tokushima, 1-1 Minamijosanjima-Cho, Tokushima 770-8502, Japan.
⁴ Faculty of Pharmacy, Yasuda Women's University, 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima 731-0153, Japan.

Abstract

A series of iridoid glycosides were isolated from the leaves of Lasianthus verticillatus (Lour.) Merr., belonging to family Rubiaceae. A new iridoid glycoside, lasianoside F (1), and three new bis-iridoid glycosides, lasianosides G-I (2-4), together with four known compounds (5-8) were isolated. The structures were established by spectroscopic methods, including 1D and 2D NMR experiments (¹H, ¹³C, DEPT, COSY, HSQC, HMBC, and NOESY) in combination with HR-ESI-MS and CD spectra.

Keywords: Lasianthus verticillatus; Rubiaceae; bis-iridoids; iridoids; lasianoside.

MeSH terms

Iridoid Glycosides / chemistry*
Nuclear Magnetic Resonance, Biomolecular
Plant Extracts / chemistry*
Plant Leaves / chemistry*
Rubiaceae / chemistry*

Substances

Iridoid Glycosides
Plant Extracts