Recent progress of antibacterial natural products: Future antibiotics candidates

Jiangkun Dai; Rui Han; Yujie Xu; Na Li; Junru Wang; Wenjia Dan

doi:10.1016/j.bioorg.2020.103922

Recent progress of antibacterial natural products: Future antibiotics candidates

Bioorg Chem. 2020 Aug:101:103922. doi: 10.1016/j.bioorg.2020.103922. Epub 2020 May 20.

Authors

Jiangkun Dai¹, Rui Han², Yujie Xu², Na Li³, Junru Wang⁴, Wenjia Dan⁵

Affiliations

¹ College of Veterinary Medicine, Northwest A&F University, Shaanxi, China(1); State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, China(1); School of Life Science and Technology, Weifang Medical University, Shandong, China(1). Electronic address: daijkun@hotmail.com.
² College of Chemistry & Pharmacy, Northwest A&F University, Shaanxi, China(1).
³ College of Food Science and Technology, Northwest University, Xi'an, China(1). Electronic address: nwuln@nwu.edu.cn.
⁴ College of Veterinary Medicine, Northwest A&F University, Shaanxi, China(1); College of Chemistry & Pharmacy, Northwest A&F University, Shaanxi, China(1). Electronic address: wangjr07@163.com.
⁵ School of Life Science and Technology, Weifang Medical University, Shandong, China(1); College of Chemistry & Pharmacy, Northwest A&F University, Shaanxi, China(1). Electronic address: dwj586@163.com.

PMID: 32559577
DOI: 10.1016/j.bioorg.2020.103922

Abstract

The discovery of novel antibacterial molecules plays a key role in solving the current antibiotic crisis issue. Natural products have long been an important source of drug discovery. Herein, we reviewed 256 natural products from 11 structural classes in the period of 2016-01/2020, which were selected by SciFinder with new compounds or new structures and MICs lower than 10 μg/mL or 10 μM as criterions. This review will provide some effective antibacterial lead compounds for medicinal chemists, which will promote the antibiotics research based on natural products to the next level.

Keywords: Antibacterial; Drug Candidates; Natural Products.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Anti-Bacterial Agents / pharmacology*
Biological Products / pharmacology*
Drug Discovery
Microbial Sensitivity Tests

Substances

Anti-Bacterial Agents
Biological Products