Understanding the Deadly Silence of Posterior Fossa A Ependymoma

Grant L Lin; Michelle Monje

doi:10.1016/j.molcel.2020.05.020

Understanding the Deadly Silence of Posterior Fossa A Ependymoma

Mol Cell. 2020 Jun 18;78(6):999-1001. doi: 10.1016/j.molcel.2020.05.020.

Authors

Grant L Lin¹, Michelle Monje²

Affiliations

¹ Department of Neurology, Stanford University, Stanford, CA, USA.
² Department of Neurology, Stanford University, Stanford, CA, USA. Electronic address: mmonje@stanford.edu.

PMID: 32559429
DOI: 10.1016/j.molcel.2020.05.020

Abstract

In a breakthrough study in a recent issue of Cell, Michealraj et al. (2020) demonstrate that posterior fossa A ependymoma, a lethal pediatric brain tumor with a silent genome, is dependent upon metabolic changes associated with hypoxia that drive the tumor's characteristic epigenetic dysregulation.

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MeSH terms

Brain Neoplasms*
Child
Ependymoma / genetics*
Epigenome
Epigenomics
Humans
Infratentorial Neoplasms / genetics*