The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

Yujie Ren; Ting Shu; Di Wu; Jingfang Mu; Chong Wang; Muhan Huang; Yang Han; Xue-Yi Zhang; Wei Zhou; Yang Qiu; Xi Zhou

doi:10.1038/s41423-020-0485-9

The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

Cell Mol Immunol. 2020 Aug;17(8):881-883. doi: 10.1038/s41423-020-0485-9. Epub 2020 Jun 18.

Authors

Yujie Ren^{1

2

3}, Ting Shu^{2

4

5}, Di Wu^{2

4}, Jingfang Mu^{2

4}, Chong Wang^{1

2

3}, Muhan Huang^{2

4}, Yang Han^{2

4

5}, Xue-Yi Zhang^{2

6}, Wei Zhou¹, Yang Qiu^{7

8

9

10}, Xi Zhou^{11

12

13

14

15

16}

Affiliations

¹ Center for Precision Translational Medicine of Wuhan Institute of Virology & Guangzhou Women and Children's Medical Center, Guangzhou Women and Children's Medical Center, Guangzhou, Guangdong, 510120, China.
² State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Wuhan, Hubei, 430071, China.
³ Center for Precision Translational Medicine of Wuhan Institute of Virology & Guangzhou Women and Children's Medical Center, Wuhan Institute of Virology, CAS, Wuhan, Hubei, 430071, China.
⁴ Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology & Wuhan Jinyintan Hospital, CAS, Wuhan, Hubei, 430023, China.
⁵ Center for Translational Medicine, Wuhan Jinyintan Hospital, Wuhan, Hubei, 430023, China.
⁶ State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei, 430072, China.
⁷ State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Wuhan, Hubei, 430071, China. yangqiu@wh.iov.cn.
⁸ Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology & Wuhan Jinyintan Hospital, CAS, Wuhan, Hubei, 430023, China. yangqiu@wh.iov.cn.
⁹ Center for Translational Medicine, Wuhan Jinyintan Hospital, Wuhan, Hubei, 430023, China. yangqiu@wh.iov.cn.
¹⁰ University of Chinese Academy of Sciences, Beijing, 100049, China. yangqiu@wh.iov.cn.
¹¹ State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Wuhan, Hubei, 430071, China. zhouxi@wh.iov.cn.
¹² Center for Precision Translational Medicine of Wuhan Institute of Virology & Guangzhou Women and Children's Medical Center, Wuhan Institute of Virology, CAS, Wuhan, Hubei, 430071, China. zhouxi@wh.iov.cn.
¹³ Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology & Wuhan Jinyintan Hospital, CAS, Wuhan, Hubei, 430023, China. zhouxi@wh.iov.cn.
¹⁴ Center for Translational Medicine, Wuhan Jinyintan Hospital, Wuhan, Hubei, 430023, China. zhouxi@wh.iov.cn.
¹⁵ State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei, 430072, China. zhouxi@wh.iov.cn.
¹⁶ University of Chinese Academy of Sciences, Beijing, 100049, China. zhouxi@wh.iov.cn.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apoptosis / genetics*
Betacoronavirus / chemistry*
COVID-19
Caspase 3 / metabolism
Chlorocebus aethiops
Coronavirus Infections / metabolism*
Coronavirus Infections / virology
HEK293 Cells
Hep G2 Cells
Humans
Pandemics
Pneumonia, Viral / metabolism*
Pneumonia, Viral / virology
SARS-CoV-2
Transfection
Vero Cells
Viral Regulatory and Accessory Proteins / genetics
Viral Regulatory and Accessory Proteins / metabolism*
Viral Structural Proteins / genetics
Viral Structural Proteins / metabolism
Viroporin Proteins

Substances

ORF3A protein, SARS coronavirus
ORF3a protein, SARS-CoV-2
Viral Regulatory and Accessory Proteins
Viral Structural Proteins
Viroporin Proteins
CASP3 protein, human
Caspase 3