pH-dependent ileocolonic drug delivery, part I: in vitro and clinical evaluation of novel systems

Annemarie Broesder; Herman J Woerdenbag; Grietje H Prins; Duong N Nguyen; Henderik W Frijlink; Wouter L J Hinrichs

doi:10.1016/j.drudis.2020.06.011

pH-dependent ileocolonic drug delivery, part I: in vitro and clinical evaluation of novel systems

Drug Discov Today. 2020 Aug;25(8):1362-1373. doi: 10.1016/j.drudis.2020.06.011. Epub 2020 Jun 15.

Authors

Annemarie Broesder¹, Herman J Woerdenbag¹, Grietje H Prins¹, Duong N Nguyen¹, Henderik W Frijlink¹, Wouter L J Hinrichs²

Affiliations

¹ University of Groningen, Groningen Research Institute of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
² University of Groningen, Groningen Research Institute of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. Electronic address: w.l.j.hinrichs@rug.nl.

PMID: 32554060
DOI: 10.1016/j.drudis.2020.06.011

Abstract

After the pH dependency of novel pH-dependent ileocolonic drug delivery systems is confirmed in vitro, their performance should be evaluated in human volunteers.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Colon / metabolism*
Drug Delivery Systems*
Humans
Hydrogen-Ion Concentration
Ileum / metabolism*