1 Department of Gastroenterology, São João Hospital Center; Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto; Department of Clinical Pharmacology, São João Hospital University Center, Porto, Portugal.
2 Centre for Health Technology and Services Research (CINTESIS); Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
3 LAQV@REQUIMTE, Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.