Evaluation of antibiotic-induced behavioral changes in mice

Hye-Joo Kwon; Afrah E Mohammed; Kamal H Eltom; Jehan S Albrahim; Najla Ali Alburae

doi:10.1016/j.physbeh.2020.113015

Evaluation of antibiotic-induced behavioral changes in mice

Physiol Behav. 2020 Sep 1:223:113015. doi: 10.1016/j.physbeh.2020.113015. Epub 2020 Jun 15.

Authors

Hye-Joo Kwon¹, Afrah E Mohammed², Kamal H Eltom³, Jehan S Albrahim⁴, Najla Ali Alburae⁵

Affiliations

¹ Biology Department, Faculty of Science, Princess Nourah bint Abdulrahman University, Riyadh 84428, Saudi Arabia; The University of Utah Asia Campus, Incheon, Korea.
² Biology Department, Faculty of Science, Princess Nourah bint Abdulrahman University, Riyadh 84428, Saudi Arabia. Electronic address: AFAMOhammed@pnu.edu.sa.
³ Unit of Animal Health and Safety of Animal Products, Institute for Studies and Promotion of Animal Exports, University of Khartoum, Shambat Postal Code 13314, Khartoum North, Sudan.
⁴ Biology Department, Faculty of Science, Princess Nourah bint Abdulrahman University, Riyadh 84428, Saudi Arabia.
⁵ Department of Biology, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.

PMID: 32553641
DOI: 10.1016/j.physbeh.2020.113015

Abstract

Gut microbiota (GM) plays a critical role in health maintenance. Previous reports connected GM with metabolic, immunologic and neurologic pathways. The main purpose of the current investigation was to study whether antibiotic-induced disturbances of GM affects psychological or behavioral conditions on mice as animal model. Mice were exposed to clindamycin or amoxicillin, and their behaviors were evaluated. Antibiotic-treated groups displayed reduced recognition memory and increased depression. No significant changes in the locomotor activity and anxiety were observed. Our data suggested that changes in GM composition by antibiotics may lead to the cognitive and behavioral deficit.

Keywords: Antibiotic; Behavior; Depression; Gut microbiota; Recognition memory.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Bacterial Agents* / toxicity
Anxiety / chemically induced
Behavior, Animal
Depression / chemically induced
Gastrointestinal Microbiome*
Mice

Substances

Anti-Bacterial Agents