Data on the evaluation of FGF2 gene expression in Colorectal Cancer

Helena Caiado; Natércia Conceição; Daniel Tiago; Ana Marreiros; Susana Vicente; Jose Luis Enriquez; Ana Margarida Vaz; Artur Antunes; Horácio Guerreiro; Paulo Caldeira; M Leonor Cancela

doi:10.1016/j.dib.2020.105765

Data on the evaluation of FGF2 gene expression in Colorectal Cancer

Data Brief. 2020 May 25:31:105765. doi: 10.1016/j.dib.2020.105765. eCollection 2020 Aug.

Authors

Helena Caiado^{1

2

3}, Natércia Conceição^{2

3

4}, Daniel Tiago^{2

5}, Ana Marreiros^{3

4}, Susana Vicente⁶, Jose Luis Enriquez⁶, Ana Margarida Vaz⁷, Artur Antunes⁷, Horácio Guerreiro⁷, Paulo Caldeira^{3

7}, M Leonor Cancela^{2

3

4

8}

Affiliations

¹ ProRegeM PhD Programme in Mechanisms of disease and regenerative medicine, University of Algarve, Faro, 8005-139, Portugal.
² Center of Marine Sciences (CCMAR), University of Algarve, Faro, 8005-139, Portugal.
³ Department of Biomedical Sciences and Medicine, University of Algarve, Faro, 8005-139, Portugal.
⁴ Algarve Biomedical Center, University of Algarve, Faro, 8005-139, Portugal.
⁵ Residency at University Hospital of Algarve, Faro 8000-386.
⁶ Pathology Department, University Hospital of Algarve, Faro, 8000-386.
⁷ Gastroenterology Department, University Hospital of Algarve, Faro, 8000-386.
⁸ Centre for Biomedical Research, University of Algarve, Faro 8000-139, Portugal.

Abstract

The data presented in this article is related with the research paper entitled "Evaluation of MGP gene expression in colorectal cancer", available on Gene journal [1]. From all the transcription factors known to regulate MGP, FGF2 is the most described in colon adenocarcinoma and colon tumor cell lines, where it was shown to: i) contribute for the invasiveness potential; and ii) promote proliferation and survival of colorectal cancer cells. These in vitro studies pose the hypothesis that FGF2 associated signaling pathways could be promoting the regulation of others genes, such as MGP, that may lead to tumor progression which ultimately could result in poor prognosis in colon adenocarcinoma.

Keywords: Colorectal Cancer (CRC); FGF2; Gene expression; Matrix gla protein; Transcription factors.