Introduction: The standard modality for the treatment of soft tissue sarcomas is a wide excision followed by radiation therapy either in the form of external beam radiation or brachytherapy. Radiation therapy thus is an integral part of management and limb salvage in these cases. This, however, subjects the irradiated tissue to a greater risk for necrosis and local infection. This study suggests a protocol to manage these infections. A multimodal approach to these problems is important. Studies have shown that the use of negative pressure wound therapy (NPWT) in non-healing wounds significantly reduces edema by removing excessive fluid from the wound bed as well as facilitating removal of the infective pathogen after an aggressive wound debridement. The author has judiciously used NPWT in each of these patients with encouraging results. With no well-defined guidelines to manage radiation-induced wound infections, this retrospective study gives an overview and protocol for a systematic approach.
Case report: This is a retrospective series of five cases managed between January 2014 and December 2016. All were men with a mean age of 30.6 years with a mean follow-up of 27 months. We analyzed their demographic, clinical data, history, wound locations, primary diagnosis on histopathology, organisms isolated on culture, surgical details, antibiotics administered, and special interventions such as skin flaps or grafting and clinical outcome.Of the five, three patients received exclusive external beam radiation therapy (EBRT) and two were given intralesional brachytherapy and EBRT. Three received additional chemotherapy. 7/9 isolated organisms were multidrug-resistant mean 5.4 cycles of NPWT after aggressive debridement was needed to achieve healthy granulation tissue bed. Wounds were closed at median 31.5 days (three split-thickness split skin grafting, one local rotation flap, and one healing with secondary intention). We had two mortalities secondary to metastasis.
Conclusion: We recommend aggressive debridement, prolonged use of NPWT in infected irradiated wounds, and appropriate antibiotics with soft tissue cover by a multidisciplinary team to achieve good results.
Keywords: Radiation; infection; negative pressure wound therapy.
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