Extended ncRNAs Interfere with Promoter Nucleosome Dynamics

Tomasz W Turowski; David Tollervey

doi:10.1016/j.tig.2020.05.011

Extended ncRNAs Interfere with Promoter Nucleosome Dynamics

Trends Genet. 2020 Sep;36(9):637-639. doi: 10.1016/j.tig.2020.05.011. Epub 2020 Jun 13.

Authors

Tomasz W Turowski¹, David Tollervey²

Affiliations

¹ Wellcome Centre for Cell Biology, The University of Edinburgh, Edinburgh, UK.
² Wellcome Centre for Cell Biology, The University of Edinburgh, Edinburgh, UK. Electronic address: d.tollervey@ed.ac.uk.

PMID: 32546405
DOI: 10.1016/j.tig.2020.05.011

Abstract

Eukaryotic genomes generate vast numbers of non-protein-coding RNAs (ncRNAs) that can inhibit mRNA synthesis through transcription interference, but the mechanisms are unclear. Gill et al. show that transcription of antisense ncRNAs induces 'elongation marks' on histones in promoter regions. These inhibit active nucleosome positioning required to maintain open transcription-initiation sites.

Keywords: antisense transcript; chromatin; nuclear surveillance; transcription.

Publication types

Comment

MeSH terms

Histones / metabolism
Nucleosomes*
Promoter Regions, Genetic
RNA, Untranslated*
Transcription, Genetic

Substances

Histones
Nucleosomes
RNA, Untranslated