Local Sourcing of Secretory Proteins in Faraway Places

Ryan J Farrell; Timothy A Ryan

doi:10.1016/j.tins.2020.06.004

Local Sourcing of Secretory Proteins in Faraway Places

Trends Neurosci. 2020 Sep;43(9):649-650. doi: 10.1016/j.tins.2020.06.004. Epub 2020 Jun 13.

Authors

Ryan J Farrell¹, Timothy A Ryan²

Affiliations

¹ Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA; David Rockefeller Graduate Program, The Rockefeller University, New York, NY 10065, USA.
² Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: taryan@med.cornell.edu.

PMID: 32546404
DOI: 10.1016/j.tins.2020.06.004

Abstract

A recent paper by Carter et al. identifies a novel organelle, the ribosome-associated vesicle (RAV), that might serve as a portable, local factory for producing proteins destined for the secretory pathway. The appearance of RAVs in dendrites suggests they may serve to generate membrane and secreted proteins in distal processes.

Keywords: endoplasmic reticulum; local translation; mitochondria.

Publication types

Comment

MeSH terms

Endoplasmic Reticulum*
Proteins
Ribosomes*

Substances

Proteins