Seizing the moment: Zebrafish epilepsy models

Kinga Gawel; Melanie Langlois; Teresa Martins; Wietske van der Ent; Ettore Tiraboschi; Maxime Jacmin; Alexander D Crawford; Camila V Esguerra

doi:10.1016/j.neubiorev.2020.06.010

Seizing the moment: Zebrafish epilepsy models

Neurosci Biobehav Rev. 2020 Sep:116:1-20. doi: 10.1016/j.neubiorev.2020.06.010. Epub 2020 Jun 13.

Authors

Kinga Gawel¹, Melanie Langlois², Teresa Martins³, Wietske van der Ent⁴, Ettore Tiraboschi⁵, Maxime Jacmin³, Alexander D Crawford⁶, Camila V Esguerra⁷

Affiliations

¹ Chemical Neuroscience Group, Centre for Molecular Medicine Norway (NCMM), University of Oslo, Gaustadalléen 21, Forskningsparken, 0349, Oslo, Norway; Department of Experimental and Clinical Pharmacology, Medical University of Lublin, Jaczewskiego St. 8b, 20-090, Lublin, Poland.
² ML Consulting, 5 rue de Marseille, 69007, Lyon, France.
³ Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belval, Luxembourg.
⁴ Chemical Neuroscience Group, Centre for Molecular Medicine Norway (NCMM), University of Oslo, Gaustadalléen 21, Forskningsparken, 0349, Oslo, Norway.
⁵ Chemical Neuroscience Group, Centre for Molecular Medicine Norway (NCMM), University of Oslo, Gaustadalléen 21, Forskningsparken, 0349, Oslo, Norway; Neurophysics Group, Center for Mind/Brain Sciences, University of Trento, Piazza Manifattura 1, Building 14, 38068, Rovereto, TN, Italy.
⁶ Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belval, Luxembourg; Faculty of Veterinary Medicine, Norwegian University of Life Sciences (NMBU), Oslo, Norway.
⁷ Chemical Neuroscience Group, Centre for Molecular Medicine Norway (NCMM), University of Oslo, Gaustadalléen 21, Forskningsparken, 0349, Oslo, Norway. Electronic address: c.v.esguerra@ncmm.uio.no.

PMID: 32544542
DOI: 10.1016/j.neubiorev.2020.06.010

Abstract

Zebrafish are now widely accepted as a valuable animal model for a number of different central nervous system (CNS) diseases. They are suitable both for elucidating the origin of these disorders and the sequence of events culminating in their onset, and for use as a high-throughput in vivo drug screening platform. The availability of powerful and effective techniques for genome manipulation allows the rapid modelling of different genetic epilepsies and of conditions with seizures as a core symptom. With this review, we seek to summarize the current knowledge about existing epilepsy/seizures models in zebrafish (both pharmacological and genetic) and compare them with equivalent rodent and human studies. New findings obtained from the zebrafish models are highlighted. We believe that this comprehensive review will highlight the value of zebrafish as a model for investigating different aspects of epilepsy and will help researchers to use these models to their full extent.

Keywords: EEG; Epilepsy; Gene; High-throughput screening; Pharmacological models; Zebrafish.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Disease Models, Animal
Epilepsy* / genetics
Seizures
Zebrafish*