Cross-talk between gut and brain elicited by physical exercise

Abstract

In recent years, a paradigm shift in the bidirectional interactions within the gut-brain axis in normal and pathologic conditions has been evidenced. Although the causal relationship is not completely known, the application of new therapeutic tools such as physical exercise has been described in several studies. However, there are caveats to consider when interpreting the effect of exercise training on the axis. Therefore, an integrative perspective of the gut and the brain's communication pathway is discussed and the role of exercise on influencing this communication highway is explained in this review.

Keywords: Bacterial metabolite; Brain; Gut; Gut peptides; Inflammatory molecules; Physical exercise.