We investigate the impact of input pulse duration and peak power of a femtosecond laser on pulse broadening and propagation losses in selected hollow-core antiresonant fiber (HC-ARF). The mixed effects of strong self-phase modulation and relatively weak Raman scattering broaden the spectral width, which in turn causes a portion of the output spectrum to exceed the transmission band of the fiber, resulting in transmission losses. By designing and setting up a gas flow control system and a vacuum system, the nonlinear behavior of the fiber filled with different pressurized gases is investigated. The experimental results show that replacing the air molecules in the fiber core with argon can weaken pulse broadening and increase the transmittable peak power by 14 MW for a given 122 MW input, while a vacuum system can reduce the nonlinearity to a larger extent, therefore enhancing the transmission of HC-ARF by at least 26 MW.