The objective of this study was to evaluate the influence of a new species of plant (Spathiphyllum blandum) in the elimination of chemical oxygen demand (COD), nitrogen, phosphorus and fecal coliforms (FCs) in mesocosms of wetlands with polyethylene terephthalate (PET) and tezontle substrates under a tropical climate. The experiments were developed at the mesocosm level in 20 experimental units; 10 were planted with Spathiphyllum blandum, five in PET substrates and five in tezontle, and 10 more were used as controls without vegetation, of which five contained tezontle and five contained PET. The systems were fed with contaminated water from the river Sordo, with a hydraulic retention time of 3 days for 12 months; samples were taken in the influent and effluents of the mesocosms every 2 weeks, with the purpose of evaluating the removal of contaminants. The results showed that presence of this species tended to improve or significantly improved the removal of COD, NH4-N, PO4-P, and FCs by 7%, 16%, 29% and 12%, respectively. It was also possible to confirm that the presence of this species reduced the rate of denitrification. These results confirm that in developing countries it is feasible to find new wetland species to be used for wastewater phytoremediation.