Proceedings of the 2019 Canadian Inflammatory Myopathy Study Symposium: Clinical Trial Readiness in Myositis

Valérie Leclair; Océane Landon-Cardinal; Rohit Aggarwal; Nick Bansback; Craig Campbell; Brian M Feldman; Martin Jarry; Suzan McNamara; Barbara White; Marie Hudson; CIMS Investigators

doi:10.3899/jrheum.200480

Proceedings of the 2019 Canadian Inflammatory Myopathy Study Symposium: Clinical Trial Readiness in Myositis

J Rheumatol. 2020 Oct 1;47(10):1584-1586. doi: 10.3899/jrheum.200480. Epub 2020 Jun 15.

Authors

Affiliations

¹ V. Leclair, MD, Department of Medicine, McGill University, and Division of Rheumatology, Jewish General Hospital, Montreal, Quebec, Canada; valerie.leclair@mcgill.ca.
² O. Landon-Cardinal, MD, Department of Medicine, Université de Montréal, and Division of Rheumatology and Research Center, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
³ R. Aggarwal, MD, MSc, Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
⁴ N. Bansback, PhD, University of British Columbia and Arthritis Research Canada, Vancouver, British Columbia, Canada.
⁵ C. Campbell, MD, Department of Pediatrics, London Children's Hospital, University of Western Ontario, London, Ontario, Canada.
⁶ B.M. Feldman, MD, MSc, Faculty of Medicine and IHPME Dalla Lana School of Public Health, University of Toronto, and Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada.
⁷ M. Jarry, Patient Advocate, S. McNamara, PhD, B. White, MD, Corbus Pharmaceutical Holdings Inc., Norwood, Massachusetts, USA.

PMID: 32541080
DOI: 10.3899/jrheum.200480

Abstract

The Canadian Inflammatory Myopathy Study (CIMS) is a multicenter prospective cohort recruiting in 8 centers across Canada. One of the aims of CIMS is to conduct and participate in clinical trials in autoimmune inflammatory myopathies (AIM). Conducting clinical trials in rare diseases such as AIM presents challenges. During this symposium, experts in the field presented different solutions to successfully conduct clinical trials in AIM, including the importance of collaboration and careful trial design, as well as training and mentoring of young investigators.

Keywords: clinical trials; dermatomyositis; inclusion body myositis; polymyositis.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Canada
Dermatomyositis*
Humans
Myositis* / drug therapy
Myositis, Inclusion Body*
Polymyositis*
Prospective Studies