Abstract
Adiponectin is a major adipokine involved in energy homeostasis that exerts insulin-sensitizing properties. The level of adiponectin is reduced in situations of insulin resistance and is negatively associated with several pathophysiological situations including abdominal obesity, metabolic syndrome, steatosis and non-alcoholic steatohepatitis, type 2 diabetes, some cancers and cognitive diseases. These aspects are discussed in this review.
Keywords:
bowel disease; cancer; dementia; inflammation; insulin resistance; leptin.
MeSH terms
-
Adiponectin / physiology*
-
Animals
-
Cognition Disorders / etiology
-
Cognition Disorders / metabolism
-
Cognition Disorders / pathology
-
Diabetes Mellitus, Type 2 / etiology
-
Diabetes Mellitus, Type 2 / metabolism
-
Diabetes Mellitus, Type 2 / pathology
-
Fatty Liver / etiology
-
Fatty Liver / metabolism
-
Humans
-
Insulin / metabolism
-
Insulin Resistance / physiology
-
Metabolic Syndrome / etiology
-
Metabolic Syndrome / metabolism
-
Metabolic Syndrome / pathology
-
Neoplasms / etiology
-
Neoplasms / metabolism
-
Neoplasms / pathology
-
Obesity / metabolism
-
Obesity / pathology
-
Obesity / physiopathology