Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging

Alexander Fedintsev; Alexey Moskalev

doi:10.1016/j.arr.2020.101097

Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging

Ageing Res Rev. 2020 Sep:62:101097. doi: 10.1016/j.arr.2020.101097. Epub 2020 Jun 12.

Authors

Alexander Fedintsev¹, Alexey Moskalev²

Affiliations

¹ Institute of Biology of FRC of Komi Scientific Center, Ural Branch of Russian Academy of Sciences, Syktyvkar, Russia.
² Institute of Biology of FRC of Komi Scientific Center, Ural Branch of Russian Academy of Sciences, Syktyvkar, Russia. Electronic address: amoskalev@ib.komisc.ru.

PMID: 32540391
DOI: 10.1016/j.arr.2020.101097

Abstract

Damage accumulation in long-living macromolecules (especially extracellular matrix (ECM) proteins, nuclear pore complex (NPC) proteins, and histones) is a missing hallmark of aging. Stochastic non-enzymatic modifications of ECM trigger cellular senescence as well as many other hallmarks of aging affect organ barriers integrity and drive tissue fibrosis. The importance of it for aging makes it a key target for interventions. The most promising of them can be AGE inhibitors (chelators, O-acetyl group or transglycating activity compounds, amadorins and amadoriases), glucosepane breakers, stimulators of elastogenesis, and RAGE antagonists.

Keywords: AGE inhibitors; Aging; Extracellular matrix; Glucosepane breakers; MRTF; ROCK; YAP/TAZ.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aging*
Extracellular Matrix
Extracellular Matrix Proteins
Fibrosis
Histones
Humans

Substances

Extracellular Matrix Proteins
Histones