Oxidative Amidation of Amines in Tandem with Transamidation: A Route to Amides Using Visible-Light Energy

J Org Chem. 2020 Jul 17;85(14):9219-9229. doi: 10.1021/acs.joc.0c01222. Epub 2020 Jun 26.

Abstract

A methodology is reported for preparing amides using amines as an acyl source. The protocol involves the visible-light-promoted oxidative amidation of amines with pyrazole to synthesize N-acyl pyrazoles followed by transamidation. By combining photoredox catalysis with oxoammonium cations in the presence of sodium persulfate as a terminal oxidant, the N-acyl pyrazoles could be prepared efficiently and effectively using blue LEDs. The transamidation step was performed without the need to purify the N-acyl pyrazole intermediate, and a range of amides were generated in good to excellent yields.

Publication types

  • Research Support, Non-U.S. Gov't