Objective: This study investigates the correlation between serum apelin and galectin-3 levels with insulin resistance (IR) in women with preeclampsia (PE).
Methods: Serum apelin, galectin-3, and insulin levels were measured in 60 PE women and 30 normotensive pregnant.
Results: The PE group had significantly lower apelin and higher galectin-3 levels than the control group. PE group exhibited dyslipidemia and had higher β-cell functions than the controls. Galectin-3 level correlates with insulin, glucose, and IR. High galectin-3 also is correlated positively with dyslipidemia.
Conclusion: In PE, there is a possible contribution of galectin-3 to the harmful effects of IR and dyslipidemia.
Keywords: Apelin; galectin-3; insulin resistance; lipid profile; preeclampsia.