Nowadays, the etiological treatment of infectious diarrhea in both acute intestinal disorders and in chronic inflammatory bowel diseases is based on the use of antibiotics.Given the global formation of antibiotic-resistant strains of many pathogens, their rapid spread and the pronounced negative side effects of antibiotics on the macro-organism, the current trend is the search and creation of new drugs based on natural raw materials. Common Sage (CS) which antimicrobial effect is known, can be used to create drugs for the complex treatment of intestinal diseases. The aim of this study was to investigate the effectiveness of the use of CS extracts for the treatment of dysbiotic disorders that occurred in experimental infectious colitis in rats. To create experimental dysbiosis, animals were administered a suspension of microorganisms S. aureus, C. perfringens, C. albicans. The effect of 50% CS extract, complex of CS phenolic compounds with L-lysine was compared with the action of the antibiotic rifaximin and placebo on different groups of animals. The study found that the use of CS extracts of the drug show in the experiment in vivo antagonistic effect, in the comparison with the antibiotic, on microorganisms, but did not inhibit the representatives of normal gut microbiota. Thus, certain efficacy of CS for the correction of dysbiotic disorders has been revealed, which may be promising for further study of the use of CS extracts in the complex treatment of colitis.