Genetics of Equine Endocrine and Metabolic Disease

Elaine Norton; Molly E McCue

doi:10.1016/j.cveq.2020.03.011

Genetics of Equine Endocrine and Metabolic Disease

Vet Clin North Am Equine Pract. 2020 Aug;36(2):341-352. doi: 10.1016/j.cveq.2020.03.011. Epub 2020 Jun 11.

Authors

Elaine Norton¹, Molly E McCue²

Affiliations

¹ Veterinary Population Medicine Department, University of Minnesota, 225 Veterinary Medical Center, 1365 Gortner Avenue, St Paul, MN 55108, USA. Electronic address: norto253@umn.edu.
² Veterinary Population Medicine Department, University of Minnesota, 225 Veterinary Medical Center, 1365 Gortner Avenue, St Paul, MN 55108, USA.

PMID: 32534851
DOI: 10.1016/j.cveq.2020.03.011

Abstract

A role for a genetic contribution to equine metabolic syndrome (EMS) and pars pituitary intermedia dysfunction (PPID) has been hypothesized. Heritability estimates of EMS biochemical measurements were consistent with moderately to highly heritable traits. Further, genome-wide association analyses have identified hundreds of regions of the genome contributing to EMS and candidate variants have been identified. The genetics of PPID has not yet been proven. Continued research for the specific genetic risk factors for both EMS and PPID is crucial for gaining a better understanding of the pathophysiology of both conditions and allowing development of genetic tests.

Keywords: Equine metabolic syndrome; Genetics; Genome-wide association analysis; Heritability; Pars pituitary intermedia dysfunction; Risk factors.

Publication types

Review

MeSH terms

Animals
Endocrine System Diseases / genetics
Endocrine System Diseases / veterinary*
Genome-Wide Association Study / veterinary
Horse Diseases / genetics*
Horses
Metabolic Diseases / genetics
Metabolic Diseases / veterinary*