Iron doped graphitic carbon nitride with peroxidase like activity for colorimetric detection of sarcosine and hydrogen peroxide

Mikrochim Acta. 2020 Jun 12;187(7):383. doi: 10.1007/s00604-020-04373-w.

Abstract

The successful synthesis is reported of Mn, Fe, Co, Ni, Cu-doped g-C3N4 nanoflakes via a simple one-step pyrolysis method, respectively. Among them, the Fe-doped g-C3N4 nanoflakes exhibited the highest peroxidase-like activity, which can be used for colorimetric detection of hydrogen peroxide (H2O2) and sarcosine (SA), within the detection ranges of 2-100 μM and 10-500 μM and detection limits of 1.8 μM and 8.6 μM, respectively. The catalytic mechanism of the Fe-doped g-C3N4 nanoflake was also explored and verified the generation of hydroxyl radical (•OH) through fluorescence method. It is believed that the Fe-doped g-C3N4 nanoflakes as enzyme mimics will greatly promote the practical applications in a variety of fields in the future including biomedical science, environmental governance, antibacterial agent, and bioimaging due to their extraordinary catalytic performance and stability. Graphical abstract.

Keywords: Colorimetric sensors; Fe-doped g-C3N4 nanoflakes; H2O2 detection; Nanozyme; Peroxidase-like activity; Sarcosine detection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzidines / chemistry
  • Catalysis
  • Chromogenic Compounds / chemistry
  • Colorimetry / methods*
  • Graphite / chemistry*
  • Hydrogen Peroxide / analysis*
  • Hydrogen Peroxide / chemistry
  • Iron / chemistry*
  • Limit of Detection
  • Nanoparticles / chemistry*
  • Nitrogen Compounds / chemistry*
  • Oxidation-Reduction
  • Sarcosine / analysis*
  • Sarcosine / chemistry
  • Sarcosine Oxidase / chemistry

Substances

  • Benzidines
  • Chromogenic Compounds
  • Nitrogen Compounds
  • graphitic carbon nitride
  • 3,3',5,5'-tetramethylbenzidine
  • Graphite
  • Hydrogen Peroxide
  • Iron
  • Sarcosine Oxidase
  • Sarcosine