Amyloid β neurotoxicity is IDO1-Kyn-AhR dependent and blocked by IDO1 inhibitor

Signal Transduct Target Ther. 2020 Jun 12;5(1):96. doi: 10.1038/s41392-020-0188-9.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / genetics
  • Alzheimer Disease / pathology
  • Amyloid beta-Peptides / genetics
  • Animals
  • Basic Helix-Loop-Helix Transcription Factors / genetics*
  • Disease Models, Animal
  • Gene Expression Regulation, Neoplastic / drug effects
  • Humans
  • Indoleamine-Pyrrole 2,3,-Dioxygenase / antagonists & inhibitors
  • Indoleamine-Pyrrole 2,3,-Dioxygenase / genetics*
  • Kynurenine / genetics*
  • Mice
  • Neurons / drug effects
  • Neurons / pathology
  • Rats
  • Receptors, Aryl Hydrocarbon / genetics*
  • Tryptophan / pharmacology

Substances

  • 1-methyl-L-tryptophan
  • AHR protein, human
  • Amyloid beta-Peptides
  • Basic Helix-Loop-Helix Transcription Factors
  • IDO1 protein, human
  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Receptors, Aryl Hydrocarbon
  • Kynurenine
  • Tryptophan