Reward Responsiveness in Suicide Attempters: An Electroencephalography/Event-Related Potential Study

Abstract

Background: The present study aimed to objectively examine the Research Domain Criteria (RDoC) subconstructs of reward anticipation and initial response to reward in adult suicide attempters, compared with nonattempters, using electroencephalography (EEG) and event-related potentials (ERPs) within the context of the RDoC-recommended experimental paradigms for these subconstructs.

Methods: Participants had either a history of at least 1 suicide attempt (n = 30) or no history of attempting suicide (n = 30). They completed diagnostic interviews, self-report questionnaires, and 2 computer-based tasks-the monetary incentive delay task and the doors task-during which continuous EEG was recorded. Temporospatial principal component analysis was used to isolate each of the ERP components of interest from other temporally or spatially overlapping components. Exploratory time-frequency analyses were also conducted to supplement the ERP analyses.

Results: Suicide attempters, compared with nonattempters, exhibited specific deficits in reward anticipation (i.e., blunted cue-P3 ERP during the monetary incentive delay task) and in initial response to reward (i.e., reduced feedback-related delta power in the gain condition of the doors task). These results were at least partially independent of current symptoms or diagnoses of depression and anxiety.

Conclusions: These findings constitute an important step in obtaining a more fine-grained understanding of the specific reward-related abnormalities that might contribute to suicide risk.

Keywords: Event-related potentials; PCA; RDoC; Reward; Suicide attempts; Time frequency.