Carboxymethyl chitosan grafted trisiloxane surfactant nanoparticles with pH sensitivity for sustained release of pesticide

Ming Zhao; Hongjun Zhou; Long Chen; Li Hao; Huayao Chen; Xinhua Zhou

doi:10.1016/j.carbpol.2020.116433

Carboxymethyl chitosan grafted trisiloxane surfactant nanoparticles with pH sensitivity for sustained release of pesticide

Carbohydr Polym. 2020 Sep 1:243:116433. doi: 10.1016/j.carbpol.2020.116433. Epub 2020 May 20.

Authors

Ming Zhao¹, Hongjun Zhou², Long Chen¹, Li Hao³, Huayao Chen³, Xinhua Zhou⁴

Affiliations

¹ School of Chemistry and Chemical Engineering, Zhongka University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, PR China.
² School of Chemistry and Chemical Engineering, Zhongka University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, PR China; Key Laboratory of Agricultural Green Fine Chemicals of Guangdong Higher Education Institution, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, PR China. Electronic address: hongjunzhou@163.com.
³ School of Chemistry and Chemical Engineering, Zhongka University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, PR China; Key Laboratory of Agricultural Green Fine Chemicals of Guangdong Higher Education Institution, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, PR China.
⁴ School of Chemistry and Chemical Engineering, Zhongka University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, PR China; Key Laboratory of Agricultural Green Fine Chemicals of Guangdong Higher Education Institution, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, PR China. Electronic address: cexinhuazhou@163.com.

PMID: 32532386
DOI: 10.1016/j.carbpol.2020.116433

Abstract

A trisiloxane surfactant (TSS) was grafted onto an intermediate, formed by the reaction of allyl glycidyl ether (AGE) with carboxymethyl chitosan (CMCS), to obtain amphiphilic CMCS-AGE-TSS. Avermectin (AVM) was used as a model pesticide and CMCS-AGE-TSS@AVM nanoparticles were prepared by self-assembly. The structures and morphologies of the nanoparticles were studied by FT-IR and ¹H NMR spectroscopy, XRD, SEM, TGA, DSC, and DLS techniques. The average particle size of CMCS-AGE-TSS@AVM was 210 nm, with encapsulation efficiency of 66 %. With increase in TSS content, the contact angle on the leaf surface decreased from 73.62° for CMCS to 49.32° for CMCS-AGE-TSS. The half-life of AVM encapsulated in the polymer shell increased from 45 min to 83 min. Moreover, sustained release of the drug showed a significant response to pH. Finally, the difference in toxicities between CMCS-AGE-TSS@AVM and pure AVM was not significant.

Keywords: Avermectin; Carboxymethyl chitosan; Sustained release; Trisiloxane surfactant; pH sensitivity.

MeSH terms

Chitosan / analogs & derivatives*
Chitosan / chemistry
Crop Protection*
Insecticides / chemistry*
Ivermectin / analogs & derivatives*
Ivermectin / chemistry
Nanoparticles / chemistry*
Siloxanes / chemistry*
Surface-Active Agents / chemistry*

Substances

Insecticides
Siloxanes
Surface-Active Agents
carboxymethyl-chitosan
trisiloxane ethoxylate
Ivermectin
avermectin
Chitosan