Venous Thromboembolism in COVID-19: Towards an Ideal Approach to Thromboprophylaxis, Screening, and Treatment

Curr Cardiol Rep. 2020 Jun 11;22(7):52. doi: 10.1007/s11886-020-01327-9.

Abstract

Purpose of review: Novel coronavirus disease 2019 (COVID-19) has been associated with an increased risk of arterial and venous thromboembolic (VTE) diseases. However, there is a limited amount of data regarding the prevention and management of VTE in severe hospitalized COVID-19 patients.

Recent findings: In this article, we review currently available clinical data, and mechanisms for COVID-associated coagulopathy, and propose algorithms for screening, prevention (including extended-duration prophylaxis), and treatment of these patients. Although these recommendations are subject to change given rapidly evolving data, we provide a framework that can guide clinicians in managing thrombotic complications in this challenging condition.

Keywords: COVID-19; Deep vein thrombosis; Extended prophylaxis; Pulmonary embolism; Thromboprophylaxis; Venous thromboembolism.

Publication types

  • Review

MeSH terms

  • Anticoagulants* / therapeutic use
  • Betacoronavirus
  • Blood Coagulation Disorders / virology*
  • COVID-19
  • Coronavirus Infections* / complications
  • Coronavirus*
  • Heparin
  • Heparin, Low-Molecular-Weight
  • Humans
  • Male
  • Pandemics*
  • Pneumonia, Viral* / complications
  • Prospective Studies
  • Retrospective Studies
  • Risk Factors
  • SARS-CoV-2
  • Venous Thromboembolism* / prevention & control
  • Venous Thromboembolism* / virology

Substances

  • Anticoagulants
  • Heparin, Low-Molecular-Weight
  • Heparin