Nearly Complete Genome Sequence of Brugia malayi Strain FR3

Alan Tracey; Jeremy M Foster; Michael Paulini; Alexandra Grote; John Mattick; Yu-Chih Tsai; Matthew Chung; James A Cotton; Tyson A Clark; Adam Geber; Nancy Holroyd; Jonas Korlach; Silvia Libro; Sara Lustigman; Michelle L Michalski; Matthew B Rogers; Alan Twaddle; Julie C Dunning Hotopp; Matthew Berriman; Elodie Ghedin

doi:10.1128/MRA.00154-20

Nearly Complete Genome Sequence of Brugia malayi Strain FR3

Microbiol Resour Announc. 2020 Jun 11;9(24):e00154-20. doi: 10.1128/MRA.00154-20.

Authors

Alan Tracey^#¹, Jeremy M Foster^#², Michael Paulini^#³, Alexandra Grote^#⁴, John Mattick^#⁵, Yu-Chih Tsai⁶, Matthew Chung⁵, James A Cotton¹, Tyson A Clark⁶, Adam Geber⁴, Nancy Holroyd¹, Jonas Korlach⁶, Silvia Libro², Sara Lustigman⁷, Michelle L Michalski⁸, Matthew B Rogers⁹, Alan Twaddle⁴, Julie C Dunning Hotopp^{10

11

12}, Matthew Berriman¹³, Elodie Ghedin^{4

14}

Affiliations

¹ Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, United Kingdom.
² Division of Protein Expression & Modification, New England Biolabs, Ipswich, Massachusetts, USA.
³ European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, United Kingdom.
⁴ Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, USA.
⁵ Institute for Genome Science, University of Maryland School of Medicine, Baltimore, Maryland, USA.
⁶ Pacific Biosciences, Menlo Park, California, USA.
⁷ Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA.
⁸ Department of Biology and Microbiology, University of Wisconsin Oshkosh, Oshkosh, Wisconsin, USA.
⁹ Department of Surgery, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
¹⁰ Institute for Genome Science, University of Maryland School of Medicine, Baltimore, Maryland, USA jdhotopp@som.umaryland.edu mb4@sanger.ac.uk.
¹¹ Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
¹² Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
¹³ Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, United Kingdom jdhotopp@som.umaryland.edu mb4@sanger.ac.uk.
¹⁴ Department of Epidemiology, College of Global Public Health, New York University, New York, New York, USA.

^# Contributed equally.

Abstract

Lymphatic filariasis affects ∼120 million people and can result in elephantiasis and hydrocele. Here, we report the nearly complete genome sequence of the best-studied causative agent of lymphatic filariasis, Brugia malayi The assembly contains four autosomes, an X chromosome, and only eight gaps but lacks a contiguous sequence for the known Y chromosome.

Abstract

Grants and funding