The plasmonic properties of individual metallic nanostructures are of great importance for application in surface science, materials science, and nanophotonics. Herein, being facilitated with a home-made flow device and pulsed laser irradiation, we proposed a batch preparation protocol towards spherical Au nanoparticles (Au NPs) and cage shell entrapped spherical core nanoparticles (Au@cAu NPs) with highly uniform morphology and a tunable size distribution. The Fano resonance behavior exhibited by the effective interaction between spherical Au NPs and the silicon surface has great potential for the design of ultrasensitive optical sensing devices. In comparison with the spherical Au NP, the individual Au@cAu NP displayed not only a red-shifted and broadened localized surface plasmon resonance (LSPR) scattering peak, but also a higher electromagnetic field enhancement. Therefore, the Au@cAu NPs offer a better choice for plasmonic enhancement-based applications in the red and near-infrared region. In general, the current work provides a new and easy method for the large-scale preparation of gold-based uniform nanostructures, and offers an avenue to understand the interference of different plasmon modes in plasmonic systems, which has potential applications in surface science.