The association of periodontal disease with the complications of diabetes mellitus. A systematic review

Anh Thi Mai Nguyen; Rahena Akhter; Siddharth Garde; Claire Scott; Stephen M Twigg; Stephen Colagiuri; Shilpi Ajwani; Joerg Eberhard

doi:10.1016/j.diabres.2020.108244

The association of periodontal disease with the complications of diabetes mellitus. A systematic review

Diabetes Res Clin Pract. 2020 Jul:165:108244. doi: 10.1016/j.diabres.2020.108244. Epub 2020 Jun 8.

Authors

Anh Thi Mai Nguyen¹, Rahena Akhter², Siddharth Garde², Claire Scott³, Stephen M Twigg⁴, Stephen Colagiuri⁵, Shilpi Ajwani⁶, Joerg Eberhard⁷

Affiliations

¹ The University of Sydney School of Dentistry, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia. Electronic address: thng4956@uni.sydney.edu.au.
² The University of Sydney School of Dentistry, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
³ Oral Health Clinic, Royal Prince Alfred Hospital, Sydney, Australia.
⁴ Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia.
⁵ Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; The Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders, University of Sydney, Sydney, Australia.
⁶ Oral Health Services, Sydney Dental Hospital, Sydney Local Health District, Australia.
⁷ The University of Sydney School of Dentistry, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.

PMID: 32526263
DOI: 10.1016/j.diabres.2020.108244

Abstract

This review investigated the association of periodontal disease with diabetes mellitus (DM) and diabetic complications. PubMed/MEDLINE was searched including search terms "periodontal" OR "periodontitis" AND "diabetic complications" OR "diabetic retinopathy" OR "diabetic nephropathy" OR "diabetic neuropathy" OR "cardiovascular disease diabetes" OR "myocardial infarction diabetes" OR "cerebrovascular disease diabetes" OR "stroke diabetes" OR "peripheral vascular disease diabetes". Fourteen studies included in this review consistently reported an increased risk for diabetic complications including microvascular, macrovascular and death in the presence of periodontal disease. Higher risks for diabetic retinopathy (odds ratios: 2.8-8.7), neuropathy (3.2-6.6), nephropathy (1.9-8.5), cardiovascular complications (1.28-17.7) and mortality (2.3-8.5) were reported for people with diabetes with periodontitis compared to those with diabetes who have no periodontitis. This novel review summarizes current data providing further evidence of a link between poor oral health and DM and its complications. It has also drawn attention to major limitations of the available data linking periodontal disease and diabetic complications.

Keywords: Diabetic complications; Macrovascular complications; Microvascular complications; Oral health; Periodontal disease; Periodontitis.

Publication types

Systematic Review

MeSH terms

Aged
Diabetes Mellitus, Type 2 / complications*
Humans
Middle Aged
Periodontal Diseases / etiology*