Abstract
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We demonstrate five consecutive cases of predominantly lobar COVID-19-associated intracerebral haemorrhage (ICH).
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Patients were typically relatively young with a severe, prolonged inflammatory prodrome.
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COVID-19-induced endotheliitis/endotheliopathy may underlie associated cerebrovascular events.
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For the clinician, anticoagulation decisions must balance risk of thrombosis with risk of haemorrhage.
MeSH terms
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Adult
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Anticoagulants / therapeutic use
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Basal Ganglia Hemorrhage / complications
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Basal Ganglia Hemorrhage / diagnostic imaging
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Basal Ganglia Hemorrhage / epidemiology
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Basal Ganglia Hemorrhage / physiopathology
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Betacoronavirus
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Brain / diagnostic imaging
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COVID-19
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Cerebral Angiography
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Cerebral Hemorrhage / complications
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Cerebral Hemorrhage / diagnostic imaging
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Cerebral Hemorrhage / epidemiology
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Cerebral Hemorrhage / physiopathology*
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Comorbidity
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Computed Tomography Angiography
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Coronavirus Infections / complications
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Coronavirus Infections / epidemiology
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Coronavirus Infections / physiopathology*
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Diabetes Mellitus, Type 2 / epidemiology
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Endothelium, Vascular / physiopathology
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Female
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Frontal Lobe / blood supply
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Heparin, Low-Molecular-Weight / therapeutic use
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Humans
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Hypertension / epidemiology
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Myocardial Ischemia / epidemiology
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Pandemics
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Pneumonia, Viral / complications
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Pneumonia, Viral / epidemiology
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Pneumonia, Viral / physiopathology*
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Pulmonary Embolism / drug therapy
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Pulmonary Embolism / epidemiology
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Retrospective Studies
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Risk Factors
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SARS-CoV-2
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Severity of Illness Index
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Tomography, X-Ray Computed
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Venous Thrombosis / drug therapy
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Venous Thrombosis / epidemiology
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Warfarin / therapeutic use
Substances
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Anticoagulants
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Heparin, Low-Molecular-Weight
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Warfarin