Dewerin and gilbertionol two new secondary metabolites from the stem bark of Gilbertiodendron dewevrei (De Wild) J. Leonard

Dietagoum Madjouka Stephanie; Fongang Fotsing Yannick Stéphane; Bankeu Kezetas Jean Jules; Fatma Kaaniche; Isabelle Kamga Mawabo; Silvère Augustin Ngouela; Norbert Sewald; Bruno Ndjakou Lenta

doi:10.1080/14786419.2020.1777120

Dewerin and gilbertionol two new secondary metabolites from the stem bark of Gilbertiodendron dewevrei (De Wild) J. Leonard

Nat Prod Res. 2022 Jan;36(1):214-222. doi: 10.1080/14786419.2020.1777120. Epub 2020 Jun 11.

Authors

Dietagoum Madjouka Stephanie¹, Fongang Fotsing Yannick Stéphane², Bankeu Kezetas Jean Jules³, Fatma Kaaniche⁴, Isabelle Kamga Mawabo⁵, Silvère Augustin Ngouela¹, Norbert Sewald⁶, Bruno Ndjakou Lenta⁷

Affiliations

¹ Faculty of Science, Department of Organic Chemistry, The University of Yaounde 1, Yaounde, Cameroon.
² Department of Chemistry, Higher Teacher Training College, University of Maroua, Maroua, Cameroon.
³ Faculty of Science, Department of Chemistry, University of Bamenda, Bambili, Cameroon.
⁴ Laboratory of Organic Chemistry (Natural Substances Team), Faculty of Science, University of Sfax, Sfax, Tunisia.
⁵ Faculty of Science, Department of Biochemistry, University of Dschang, Dschang, Cameroon.
⁶ Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, Bielefeld, Germany.
⁷ Department of Chemistry, Higher Teacher Training College, University of Yaoundé, Yaoundé, Cameroon.

PMID: 32524849
DOI: 10.1080/14786419.2020.1777120

Abstract

The phytochemical investigation of the methanol extract of the stem bark of Gilbertiodendron dewevrei led to the isolation of two new secondary metabolites, 5,7-dihydroxy-4'-methoxyisoflavan-2,4-dione (1) and 23-hydroxy-2-tricosanone (2) along with 19 known compounds (3-21). The structure of these compounds were established by interpretation of their spectral data, mainly HR-TOFESIMS, 1 D NMR (¹H, ¹³C and DEPT) and 2 D NMR (¹H-¹H COSY, HSQC, HMBC, and NOESY), and by comparison with those reported in the literature. The methanol extract and some isolates were screened for their antiradical, antibacterial, and inhibitory properties against acetylcholinesterase.

Keywords: Caesalpinioideae; Gilbertiodendron dewevrei; bioassays; fatty ketone; isoflavone.

MeSH terms

Acetylcholinesterase
Fabaceae*
Magnetic Resonance Spectroscopy
Methanol
Molecular Structure
Plant Bark*

Substances

Acetylcholinesterase
Methanol