A three-channel fluorescent probe to image mitochondrial stress

Huawei Niu; Jun Tang; Xiaofei Zhu; Zipeng Li; Yongru Zhang; Yong Ye; Yufen Zhao

doi:10.1039/d0cc02668a

A three-channel fluorescent probe to image mitochondrial stress

Chem Commun (Camb). 2020 Jul 14;56(56):7710-7713. doi: 10.1039/d0cc02668a.

Authors

Huawei Niu¹, Jun Tang², Xiaofei Zhu², Zipeng Li², Yongru Zhang², Yong Ye², Yufen Zhao³

Affiliations

¹ Green Catalysis Center, College of Chemistry, Zhengzhou University, Zhengzhou 450001, P. R. China. yeyong03@tsinghua.org.cn and College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, 471000, China.
² Green Catalysis Center, College of Chemistry, Zhengzhou University, Zhengzhou 450001, P. R. China. yeyong03@tsinghua.org.cn.
³ Green Catalysis Center, College of Chemistry, Zhengzhou University, Zhengzhou 450001, P. R. China. yeyong03@tsinghua.org.cn and Institute of Drug Discovery Technology, Ningbo University, Ningbo, 450052, China.

PMID: 32524110
DOI: 10.1039/d0cc02668a

Abstract

Dual-recognition probes based on one reacting site inevitably encounter competition problems. Here, NPClA, a two-photon fluorescent probe based on a dual-site response for SO2/HOCl, was developed and applied in imaging mitochondrial stress.

MeSH terms

Carbon-13 Magnetic Resonance Spectroscopy
Fluorescent Dyes / chemistry*
HeLa Cells
Humans
MCF-7 Cells
Mass Spectrometry
Mitochondria / metabolism
Mitochondria / physiology*
Molecular Structure
Proton Magnetic Resonance Spectroscopy
Stress, Physiological*
Sulfur Dioxide / metabolism

Substances

Fluorescent Dyes
Sulfur Dioxide