Laboratory Biosafety Considerations of SARS-CoV-2 at Biosafety Level 2

Health Secur. 2020 May/Jun;18(3):232-236. doi: 10.1089/hs.2020.0021. Epub 2020 Jun 9.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen that causes coronavirus disease 2019 (COVID-19), which was first detected in Wuhan, China. Recent studies have updated the epidemiologic and clinical characteristics of COVID-19 continuously. In China, diagnostic tests and laboratory tests of specimens from persons under investigation are usually performed in a biosafety level 2 environment. Laboratory staff may be at greater risk of exposure due to a higher concentration and invasiveness of emerging pathogens. Current infection prevention strategies are based on lessons learned from severe acute respiratory syndrome, expert judgments, and related regulations. This article summarizes biosafety prevention and control measures performed in severe acute respiratory syndrome coronavirus 2 testing activities and provides practical suggestions for laboratory staff to avoid laboratory-acquired infections in dealing with public health emergencies.

Keywords: COVID-19; Laboratory infection; Laboratory safety; Personal protective equipment; SARS-CoV-2.

Publication types

  • Review

MeSH terms

  • Betacoronavirus
  • COVID-19
  • COVID-19 Testing
  • China
  • Clinical Laboratory Techniques / methods*
  • Containment of Biohazards / methods*
  • Coronavirus Infections / blood*
  • Coronavirus Infections / diagnosis
  • Coronavirus Infections / epidemiology
  • Disinfection / organization & administration
  • Female
  • Humans
  • Laboratories / organization & administration
  • Laboratory Infection / prevention & control*
  • Male
  • Occupational Health
  • Pandemics
  • Personal Protective Equipment / statistics & numerical data*
  • Pneumonia, Viral / blood*
  • Pneumonia, Viral / epidemiology
  • SARS-CoV-2
  • Specimen Handling / methods