Abstract
A conjugate of a Mn-based superoxide dismutase mimic with a Re-based multimodal probe 1[combining low line] was studied in a cellular model of oxidative stress. Its speciation was investigated using Re and Mn X-fluorescence. Interestingly, 1[combining low line] shows a distribution different from its unconjugated analogue but a similar concentration in mitochondria and a similar bioactivity.
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / metabolism
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Coordination Complexes / chemistry
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Coordination Complexes / metabolism
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Coordination Complexes / pharmacology*
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Humans
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Molecular Structure
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Oxidative Stress / drug effects
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Rhenium / chemistry
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Rhenium / metabolism
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Rhenium / pharmacology*
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Superoxide Dismutase / metabolism*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Coordination Complexes
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Rhenium
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Superoxide Dismutase