Abstract
The optically active stereomers of some 3-(fluoro-, chloro-, bromophenyl)-2-biphenylyl-3-hydroxypropionic acids were prepared and tested for antiinflammatory activity. Surprisingly, the four bromo-isomers were the most active ones, particularly in the threo configuration.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal* / therapeutic use
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Chemical Phenomena
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Chemistry, Physical
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Edema / drug therapy
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Phenylpropionates* / therapeutic use
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Stereoisomerism
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Phenylpropionates