Nonsteroidal antiinflammatory agents. XVIII - Stereomeric optically active halogenophenyl-biphenylyl-hydroxypropionic acids

Farmaco Sci. 1988 Nov;43(11):909-19.

Abstract

The optically active stereomers of some 3-(fluoro-, chloro-, bromophenyl)-2-biphenylyl-3-hydroxypropionic acids were prepared and tested for antiinflammatory activity. Surprisingly, the four bromo-isomers were the most active ones, particularly in the threo configuration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal* / therapeutic use
  • Chemical Phenomena
  • Chemistry, Physical
  • Edema / drug therapy
  • Phenylpropionates* / therapeutic use
  • Stereoisomerism

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Phenylpropionates