Abstract
We report the results of the antiulcer activity of some arylthiomethylpyridine compounds. Some of these showed gastroprotective activity against 96% ethanol-induced gastric lesions greater than Omeprazole. However they possess antiulcer properties lower than the reference compound against Indomethacin-induced gastric ulcers.
MeSH terms
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2-Pyridinylmethylsulfinylbenzimidazoles
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Animals
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Anti-Ulcer Agents / chemical synthesis*
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Anti-Ulcer Agents / therapeutic use
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Benzimidazoles / chemical synthesis*
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Benzimidazoles / therapeutic use
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Indomethacin
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Male
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Omeprazole / therapeutic use
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Pyridines / chemical synthesis*
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Pyridines / therapeutic use
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Rats
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Rats, Inbred Strains
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Stomach Ulcer / chemically induced
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Stomach Ulcer / drug therapy
Substances
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2-Pyridinylmethylsulfinylbenzimidazoles
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Anti-Ulcer Agents
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Benzimidazoles
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Pyridines
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timoprazole
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Omeprazole
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Indomethacin