[Synthesis and anti-ulcer activity of some new compounds with arylthiomethyl-pyridine structure]

Farmaco Sci. 1988 Nov;43(11):901-8.
[Article in Italian]

Abstract

We report the results of the antiulcer activity of some arylthiomethylpyridine compounds. Some of these showed gastroprotective activity against 96% ethanol-induced gastric lesions greater than Omeprazole. However they possess antiulcer properties lower than the reference compound against Indomethacin-induced gastric ulcers.

Publication types

  • English Abstract

MeSH terms

  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Animals
  • Anti-Ulcer Agents / chemical synthesis*
  • Anti-Ulcer Agents / therapeutic use
  • Benzimidazoles / chemical synthesis*
  • Benzimidazoles / therapeutic use
  • Indomethacin
  • Male
  • Omeprazole / therapeutic use
  • Pyridines / chemical synthesis*
  • Pyridines / therapeutic use
  • Rats
  • Rats, Inbred Strains
  • Stomach Ulcer / chemically induced
  • Stomach Ulcer / drug therapy

Substances

  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Anti-Ulcer Agents
  • Benzimidazoles
  • Pyridines
  • timoprazole
  • Omeprazole
  • Indomethacin