Malignant round cell tumor with SS18-POU5F1 fusion: is it a myoepithelial neoplasm, a synovial sarcoma or a new entity?

Histopathology. 2020 Oct;77(4):681-684. doi: 10.1111/his.14171. Epub 2020 Jul 28.

Affiliations

¹ Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
² Gene Expression & Genotyping, Interdisciplinary Center of Biotechnology Research, University of Florida, Gainesville, FL, USA.
³ Division of Hematology and Oncology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA.
⁴ Division of Pediatric Surgery, Department of Surgery, University of Florida College of Medicine, Gainesville, FL, USA.

PMID: 32516451
DOI: 10.1111/his.14171

No abstract available

Keywords: Ewing-like sarcoma; SS18; myoepithelial tumor of soft tissue; round cell sarcoma.

Publication types

Case Reports
Letter

MeSH terms

Back / pathology
Biomarkers, Tumor / metabolism
Child
Female
Humans
In Situ Hybridization, Fluorescence / methods
Lymph Nodes / pathology
Myoepithelioma* / diagnosis
Myoepithelioma* / pathology
Neoplasm Staging
Octamer Transcription Factor-3* / metabolism
Oncogene Proteins, Fusion / metabolism
Pathology, Molecular / methods
Proto-Oncogene Proteins* / metabolism
Repressor Proteins* / metabolism
Sarcoma, Synovial* / diagnosis
Sarcoma, Synovial* / pathology
Soft Tissue Neoplasms / classification*
Soft Tissue Neoplasms / diagnosis
Soft Tissue Neoplasms / pathology

Substances

Biomarkers, Tumor
Octamer Transcription Factor-3
Oncogene Proteins, Fusion
POU5F1 protein, human
Proto-Oncogene Proteins
Repressor Proteins
SS18 protein, human

Grants and funding

University of Florida, Department of Pathology/International