Synthesis, characterization and electrochemical properties of some biologically important indole-based-sulfonamide derivatives

Mohamed Ibrahim; Muhammed Taha; Noor B Almandil; Abdel-Nasser Kawde; Muhammad Nawaz

doi:10.1186/s13065-020-00691-5

Synthesis, characterization and electrochemical properties of some biologically important indole-based-sulfonamide derivatives

BMC Chem. 2020 May 27;14(1):38. doi: 10.1186/s13065-020-00691-5. eCollection 2020 Dec.

Authors

Mohamed Ibrahim¹, Muhammed Taha¹, Noor B Almandil¹, Abdel-Nasser Kawde², Muhammad Nawaz³

Affiliations

¹ Department of Clinical Pharmacy Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam, 31441 Saudi Arabia.
² Chemistry Department, College of Sciences, King Fahd University of Petroleum and Minerals, Dhahran, 31261 Saudi Arabia.
³ Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam, 31441 Saudi Arabia.

Abstract

A new series of indole-based-sulfonamide derivatives (A1-A8) was synthesized by treating 5-fluoro-1H-indole-3-carbohydrazide with different aryl-sulfonyl chloride in the presence of pyridine. All synthesized derivatives (A1-A8) were characterized by different analytical methods. The electrochemical behavior of these compounds (A1-A8) was investigated in detail using cyclic voltammetry (CV) and square wave voltammetry (SWV) at the pencil graphite electrode (PGE). In the present study, the redox behavior of all derivatives varies due to the nature of substitutions in the indole sulfonamide moiety. Various fundamental electrochemical parameters, including the standard heterogeneous rate constants (k_s), and the electroactive surface coverage (Г) were calculated from the obtained CVs. The obtained results shed light on the understanding of structure-activity relationships of this class of compounds.

Keywords: Electrochemical parameters; Indole sulfonamide derivatives; Oxidation; Synthesis; Voltammetry.