The 3D MHD nonlinear radiative hybrid nanofluid flow across an irregular dimension sheet with slip effect is studied numerically. The hybrid nanofluid consists of copper oxide (CuO) and magnesium oxide (MgO) nanoparticles embedded in methanol or methyl alcohol (MA). The governing PDEs' are altered as ODEs' using similarities and numerical solutions are attained using shooting scheme. The role of corporal factors on the transport phenomenon is analyzed and reflected by plots and numerical interpretations. Simultaneous solutions presented for CuO-MA nanofluid and CuO-MgO/MA hybrid nanofluid. Results ascertain that the temperature and flow boundary layer thicknesses are not unique for the hybrid nanofluid and nanofluid. The heat transfer enactment of CuO-MA nanofluid is high when equated to CuO-MgO/MA hybrid nanofluid. This concludes that the CuO-MgO combination works as a good insulator.