Intracranial-to-central venous pressure gap predicts the responsiveness of intracranial pressure to PEEP in patients with traumatic brain injury: a prospective cohort study

Abstract

Background: Mechanical ventilation (MV) with positive end-expiratory pressure (PEEP) is commonly applied in patients with severe traumatic brain injury (sTBI). However, the individual responsiveness of intracranial pressure (ICP) to PEEP varies. Thus, identifying an indicator detecting ICP responsiveness to PEEP is of great significance. As central venous pressure (CVP) could act as an intermediary to transduce pressure from PEEP to ICP, we developed a new indicator, P_ICGap, representing the gap between baseline ICP and baseline CVP. The aim of the current study was to explore the relationship between P_ICGap and ICP responsiveness to PEEP.

Methods: A total of 112 patients with sTBI undergoing MV were enrolled in this prospective cohort study. ICP, CVP, cerebral perfusion pressure (CPP), static compliance of the respiratory system (Cst), and end-tidal carbon dioxide pressure (PetCO₂) were recorded at the initial (3 cmH₂O) and adjusted (15 cmH₂O) levels of PEEP. P_ICGap was assessed as baseline ICP - baseline CVP (when PEEP = 3 cmH₂O). The patients were classified into the ICP responder and non-responder groups based on whether ICP increment with PEEP adjusted from 3 cmH₂O to 15 cmH₂O was greater than 20% of baseline ICP. The above parameters were compared between the two groups, and prediction of ICP responsiveness to PEEP adjustment was evaluated by receiver operating characteristic (ROC) curve analysis.

Results: Compared with the non-responder group, the responder group had lower P_ICGap (1.63 ± 1.33 versus 6.56 ± 2.46 mmHg; p < 0.001), lower baseline ICP, and higher baseline CVP. ROC curve analysis suggested that P_ICGap was a stronger predictive indicator of ICP responsiveness to PEEP (AUC = 0.957, 95%CI 0.918-0.996; p < 0.001) compared with baseline ICP and baseline CVP, with favorable sensitivity (95.24, 95%CI 86.91-98.70%) and specificity (87.6, 95%CI 75.76-94.27%), at a cut off value of 2.5 mmHg.

Conclusion: The impact of PEEP on ICP depends on the gap between baseline ICP and baseline CVP, i.e. P_ICGap. In addition, P_ICGap is a potential predictor of ICP responsiveness to PEEP adjustment in patients with sTBI.

Keywords: Central venous pressure; Intracranial pressure; Mechanical ventilation; PICGap; Positive end-expiratory pressure; Traumatic brain injury.