Intake of Camelina Sativa Oil and Fatty Fish Alter the Plasma Lipid Mediator Profile in Subjects with Impaired Glucose Metabolism - A Randomized Controlled Trial

Topi Meuronen; Maria A Lankinen; Alexander Fauland; Bun-Ichi Shimizu; Vanessa D de Mello; David E Laaksonen; Craig E Wheelock; Arja T Erkkilä; Ursula S Schwab

doi:10.1016/j.plefa.2020.102143

Intake of Camelina Sativa Oil and Fatty Fish Alter the Plasma Lipid Mediator Profile in Subjects with Impaired Glucose Metabolism - A Randomized Controlled Trial

Prostaglandins Leukot Essent Fatty Acids. 2020 Aug:159:102143. doi: 10.1016/j.plefa.2020.102143. Epub 2020 May 30.

Authors

Topi Meuronen¹, Maria A Lankinen², Alexander Fauland³, Bun-Ichi Shimizu³, Vanessa D de Mello², David E Laaksonen⁴, Craig E Wheelock³, Arja T Erkkilä², Ursula S Schwab⁵

Affiliations

¹ Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, 70211 Kuopio, Finland. Electronic address: topim@uef.fi.
² Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, 70211 Kuopio, Finland.
³ Division of Physiological Chemistry 2, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
⁴ Department of Medicine, Endocrinology and Clinical Nutrition, Kuopio University Hospital, 70029 Kuopio University Hospital, Finland; Institute of Biomedicine, Physiology, University of Eastern Finland, 70211 Kuopio, Finland.
⁵ Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, 70211 Kuopio, Finland; Department of Medicine, Endocrinology and Clinical Nutrition, Kuopio University Hospital, 70029 Kuopio University Hospital, Finland.

PMID: 32512364
DOI: 10.1016/j.plefa.2020.102143

Abstract

n-3 and n-6 polyunsaturated fatty acids (PUFAs) and their lipid mediator metabolites are associated with inflammation. We investigated the effect of dietary intake of plant- and animal-derived n-3 PUFAs and fish protein on the circulatory concentrations of lipid mediators. Seventy-nine subjects with impaired fasting glucose who completed the controlled dietary intervention after randomization to the fatty fish (FF, n=20), lean fish (LF, n=21), Camelina sativa oil (CSO, n=18) or control group (n=20) for 12 weeks were studied. Lipid mediator profiling from fasting plasma samples before and after the intervention was performed by liquid chromatography-mass spectrometry (LC-MS/MS). The FF diet increased concentrations of 18-hydroxyeicosapentaenoic acid (18-HEPE) and 4- and 17-hydroxydocosahexaenoic acid (4-, 17-HDoHE) derived from eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), respectively. Concentrations of lipid mediators derived from α-linolenic acid (ALA) increased and arachidonic acid (AA) derived 5-iso prostaglandin F_2α-VI decreased in the CSO group. There were no significant changes in lipid mediators in the LF group. The dietary intake of both plant and animal-based n-3 PUFAs increased circulatory concentrations of lipid mediators with potential anti-inflammatory properties.

Trial registration: ClinicalTrials.gov NCT01768429.

Keywords: Camelina sativa; DHA; EPA; lipid mediator; α-linolenic acid.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Brassicaceae*
Female
Fish Oils
Fish Proteins, Dietary / administration & dosage*
Glucose Metabolism Disorders / blood*
Glucose Metabolism Disorders / diet therapy*
Humans
Lipids / blood*
Male
Middle Aged
Plant Oils / administration & dosage*

Substances

Fish Oils
Fish Proteins, Dietary
Lipids
Plant Oils

Associated data

ClinicalTrials.gov/NCT01768429