Homotypic Fusion Generates Multinucleated Cardiomyocytes in the Murine Heart

Circulation. 2020 Jun 9;141(23):1940-1942. doi: 10.1161/CIRCULATIONAHA.119.043530. Epub 2020 Jun 8.

Authors

Shah R Ali¹, Ivan Menendez-Montes¹, Jane Warshaw¹, Feng Xiao¹, Hesham A Sadek^{1

2

3

4}

Affiliations

¹ Departments of Internal Medicine/Cardiology (S.R.A., I.M.-M., J.W., F.X., H.A.S.), University of Texas Southwestern Medical Center, Dallas.
² Radiation Oncology, Molecular Biology (H.A.S.), University of Texas Southwestern Medical Center, Dallas.
³ Biophysics (H.A.S.), University of Texas Southwestern Medical Center, Dallas.
⁴ Center for Regenerative Science and Medicine (H.A.S.), University of Texas Southwestern Medical Center, Dallas.

PMID: 32510998
DOI: 10.1161/CIRCULATIONAHA.119.043530

No abstract available

Keywords: Cre recombinase; cardiac; cell fusion; cell nucleus; mice; mitosis; myocytes; postnatal development.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Fusion / methods*
Fluorescent Dyes / analysis
Fluorescent Dyes / metabolism
Mice
Mice, Transgenic
Myocardium / chemistry
Myocardium / metabolism*
Myocytes, Cardiac / chemistry*
Myocytes, Cardiac / drug effects
Myocytes, Cardiac / metabolism*
Tamoxifen / pharmacology

Substances

Fluorescent Dyes
Tamoxifen

Grants and funding