Electrochemiluminescent detection of glucose in human serum by BODIPY-based chemodosimeters for hydrogen peroxide using accelerated self-immolation of boronates

Yon Namkoong; Jinrok Oh; Jong-In Hong

doi:10.1039/d0cc03315d

Electrochemiluminescent detection of glucose in human serum by BODIPY-based chemodosimeters for hydrogen peroxide using accelerated self-immolation of boronates

Chem Commun (Camb). 2020 Jul 14;56(55):7577-7580. doi: 10.1039/d0cc03315d. Epub 2020 Jun 8.

Authors

Yon Namkoong¹, Jinrok Oh, Jong-In Hong

Affiliation

¹ Department of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea. ihong@snu.ac.kr.

PMID: 32510098
DOI: 10.1039/d0cc03315d

Abstract

BODIPY-based ECL chemodosimeters were developed for the detection of hydrogen peroxide. The reactivity of boronate towards hydrogen peroxide was enhanced by adjacent fluorine atoms. In combination with glucose oxidase, a fluorine-substituted probe successfully quantified the glucose level in human serum, providing its potential as a versatile tool in point-of-care testing applications.

MeSH terms

Blood Glucose / analysis*
Blood Glucose / chemistry
Electrochemical Techniques / methods
Fluorescent Dyes / chemistry*
Glucose Oxidase / chemistry
Humans
Hydrogen Peroxide / analysis
Hydrogen Peroxide / chemistry
Limit of Detection
Oxidation-Reduction
Porphobilinogen / analogs & derivatives*
Porphobilinogen / chemistry
Spectrometry, Fluorescence

Substances

3-anilino difluoroboron dipyrromethene
Blood Glucose
Fluorescent Dyes
Porphobilinogen
Hydrogen Peroxide
Glucose Oxidase