In light-sensitive drug delivery system nanoparticles mediate oxidative stress

Wei Xiang; Long Chen

In light-sensitive drug delivery system nanoparticles mediate oxidative stress

Am J Transl Res. 2020 May 15;12(5):1469-1480. eCollection 2020.

Authors

Wei Xiang¹, Long Chen²

Affiliations

¹ Yangtze Normal University, College of Modern Agriculture and Bioengineering Chongqing, China.
² Bioengineering Institute of Chongqing University 174 Shazheng Street, Chongqing, China.

PMID: 32509156
PMCID: PMC7270018

Abstract

In light-sensitive drug delivery systems, more and more nanoparticles were applied to load various drug molecules. However, few studies focused on their biomedical effects such as the regulation of heme oxygenase-1 (HO-1) expression and reactive oxygen species (ROS) generation which could influence cellular redox reaction. In the present article, through review of literature, analysis of high-throughput sequencing database, the mechanisms of drug delivery based on organic (poly-lactic-co-glycolic acid (PLGA) and polyethylene glycol (PEG)) and inorganic (Au, ZnO, SiO₂ and TiO₂) nanoparticles were introduced briefly. Besides, it was also expounded that nuclear factor-erythroid 2 (NF-E2)-related factor 2/BTB domain and CNC homolog 1 (Nrf2/Bach1) might be involved in the regulation of HO-1 and the quantum effect of photon altered ROS generation. The exogenous nanoparticles certainly have various biomedical effects that even affect the pathogenesis of some diseases like atopic dermatitis. Thus, biomedical effect of nanoparticles depends on HO-1/ROS needs further research.

Keywords: Drug delivery system; HO-1; Nrf2; ROS; atopic dermatitis; microRNA; nanoparticles.

Publication types

Review