High expression of ZNF93 promotes proliferation and migration of ovarian cancer cells and relates to poor prognosis

Xiao-Xiao Cui; Chen Zhou; Huan Lu; Yan-Li Han; Feng-Mian Wang; Wei-Rong Fan; Yuan Ren; Rong Zhang

High expression of ZNF93 promotes proliferation and migration of ovarian cancer cells and relates to poor prognosis

Int J Clin Exp Pathol. 2020 May 1;13(5):944-953. eCollection 2020.

Authors

Xiao-Xiao Cui^{1

2}, Chen Zhou³, Huan Lu², Yan-Li Han¹, Feng-Mian Wang², Wei-Rong Fan², Yuan Ren^{1

2}, Rong Zhang^{1

2}

Affiliations

¹ Anhui University of Science and Technology Huainan, P. R. China.
² Department of Obstetrics and Gynecology, Health Sciences Affiliated Sixth People's Hospital South Campus Shanghai, P. R. China.
³ Department of Gynecology, Changzhou No. 2 People's Hospital Jiangsu, P. R. China.

PMID: 32509065
PMCID: PMC7270678

Abstract

Ovarian cancer (OC) is most common type of gynecologic cancer and is frequently lethal. It is important to determine the pathologic mechanisms underlying OC. ZNF93 is a member of the zinc finger protein family. Abnormal expression of ZNF93 has been observed in various tumor cells. However, its clinical significance and biologic function in ovarian cancer remain unclear. In the present study, we established that ZNF93 expression was highly up-regulated in OC samples and was closely correlated with clinical stage, indicating poor prognosis. We then established that ZNF93 promoted OC cell proliferation and migration. The results of our study may provide insight into the use of ZNF93 as a marker of clinical outcome and as a potential therapeutic target in OC.

Keywords: Ovarian cancer; cell migration; cell proliferation; small interfering siRNA; transcription factor ZNF93.