Antiepileptic Drugs and Bone Health: Current Concepts

Antonio Siniscalchi; Sean Murphy; Erika Cione; Leonardo Piro; Giovambattista De Sarro; Luca Gallelli

Antiepileptic Drugs and Bone Health: Current Concepts

Psychopharmacol Bull. 2020 May 19;50(2):36-44.

Authors

Antonio Siniscalchi¹, Sean Murphy¹, Erika Cione¹, Leonardo Piro¹, Giovambattista De Sarro¹, Luca Gallelli¹

Affiliation

¹ Siniscalchi, Department of Neurology and Stroke Unit, Annunziata Hospital of Cosenza, Cosenza, Italy. Murphy, General Medicine, Stroke Unit, Mater Misericordiae University Hospital, Dublin, Ireland. Cione, Department of Pharmacy, Health and Nutritional Sciences, Department of Excellence 2018-2022, University of Calabria, Rende (CS), Italy. Piro, Orthopedic Unit, Corigliano-Rossano Hospital, ASP Cosenza, Italy. De Sarro and Gallelli, Chair of Pharmacology, Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology Unit, Mater Domini University Hospital, Catanzaro, Italy.

PMID: 32508365
PMCID: PMC7255839

Abstract

Chronic use of antiepileptic drugs (AEDs) can induce the development of adverse effects on bone metabolism. In epileptic patients treated with AED, the monitoring of biochemical markers of bone turnover, such as the measurement of serum 25 (OH) vitamin D, bone mineral density, before the beginning of the treatment and during the follow-up is not routinely required. In the future, monitoring of biochemical markers in epileptic patients treated with AED may help us for adequate prevention therapy.

Keywords: antiepileptic drugs; biochemical markers; bone metabolism; vitamin D metabolism.

Publication types

Review

MeSH terms

Anticonvulsants* / adverse effects
Bone Density
Bone and Bones
Epilepsy* / drug therapy
Humans
Vitamin D

Substances

Anticonvulsants
Vitamin D