New "naked-eye" colori/fluorimetric "turn-on" chemosensor: Ultrafast and ultrasensitive detection of hydrazine in ∼100% aqueous solution and its bio-imaging in living cells

Anal Chim Acta. 2020 Aug 1:1123:64-72. doi: 10.1016/j.aca.2020.04.079. Epub 2020 May 13.

Abstract

A new oligothiophene derivative (3TY) was synthesized, and used as a highly selective hydrazine (N2H4) chemosensor in ∼100% aqueous solution with "naked-eye" colorimetric and "turn-on" fluorimetric response. This chemosensor 3TY enabled ultrafast and ultrasensitive detection of hydrazine with ultralow detection limit of 1.45 nM (0.04 ppb) in a wide sensing pH range from 6 to 10. The sensing mechanism of 3TY toward hydrazine was strongly and fully confirmed. More importantly, colorimetric paper test strip and solid support silica are easily prepared by 3TY for on-site and real-time detection of hydrazine. Furthermore, 3TY displays many potential applications for detecting N2H4 in environmental water and human urine along with bio-imaging in living HeLa cells.

Keywords: Bio-imaging; Chemosensor; Colorimetric; Fluorimetric; Hydrazine; Oligothiophene derivative.

MeSH terms

  • Colorimetry*
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • Fluorometry*
  • HeLa Cells
  • Humans
  • Hydrazines / analysis*
  • Molecular Structure
  • Optical Imaging*
  • Quantum Theory
  • Solutions
  • Thiophenes / chemical synthesis
  • Thiophenes / chemistry*
  • Water / chemistry

Substances

  • Fluorescent Dyes
  • Hydrazines
  • Solutions
  • Thiophenes
  • Water
  • hydrazine