Challenges in Reirradiation of Intrahepatic Tumors

Semin Radiat Oncol. 2020 Jul;30(3):242-252. doi: 10.1016/j.semradonc.2020.02.004.

Abstract

Definitive reirradiation using a stereotactic technique is an effective local treatment option for both recurrent liver metastases and recurrent primary liver cancers. The tolerance of the liver, bile ducts, and surrounding gastrointestinal luminal organs must be respected to ensure safe retreatment. The risks associated with retreatment to these organs must be carefully balanced with the probability of clinical benefit. We present 2 cases for consideration of repeat irradiation along with the opinions of 4 experts, along with conclusions about recommendations.

Publication types

  • Clinical Conference

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols
  • Carcinoma, Hepatocellular / diagnostic imaging
  • Carcinoma, Hepatocellular / pathology
  • Carcinoma, Hepatocellular / radiotherapy*
  • Colonic Neoplasms / pathology
  • Colonic Neoplasms / therapy
  • Disease Progression
  • Dose Fractionation, Radiation
  • Fluorouracil
  • Humans
  • Leucovorin
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / radiotherapy*
  • Liver Neoplasms / secondary
  • Male
  • Neoplasm Recurrence, Local / diagnostic imaging
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / radiotherapy*
  • Neoplasm Staging
  • Organoplatinum Compounds
  • Organs at Risk
  • Radiotherapy Dosage
  • Re-Irradiation / methods*

Substances

  • Organoplatinum Compounds
  • Leucovorin
  • Fluorouracil

Supplementary concepts

  • Folfox protocol