The impact of metabolic syndrome (MetS) on surgical outcome for patients with mostly HBV-related hepatocellular carcinoma (HCC) underwent hepatectomy

Yunhong Tian; Tie Li; Shouliang Qi; Hani Alhourani; Binyu Luo; Junjie Chenqin; Qizhong Fu; Yong Peng; Jianlin Wu

doi:10.1002/jso.26055

The impact of metabolic syndrome (MetS) on surgical outcome for patients with mostly HBV-related hepatocellular carcinoma (HCC) underwent hepatectomy

J Surg Oncol. 2020 Sep;122(4):699-706. doi: 10.1002/jso.26055. Epub 2020 Jun 5.

Authors

Yunhong Tian^{1

2}, Tie Li³, Shouliang Qi⁴, Hani Alhourani⁵, Binyu Luo¹, Junjie Chenqin^{2

6}, Qizhong Fu³, Yong Peng¹, Jianlin Wu⁷

Affiliations

¹ Department of General Surgery, Nanchong Central Hospital, The Second Clinical Medical College, North Sichuan Medical College (University), Nanchong, Sichuan, China.
² Department of hepatic surgery, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China.
³ Department of Surgery, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
⁴ Department of Biomedical Imaging, College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, China.
⁵ Department of Radiology, Wayne State University, Detroit, Michigan.
⁶ Department of Clinical Medicine, Graduate School of Soochow University, Suzhou, China.
⁷ Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.

PMID: 32502302
DOI: 10.1002/jso.26055

Abstract

Background and objectives: The impact of metabolic syndrome (MetS) on surgical outcome, mostly in patients with HBV-related hepatocellular carcinoma (HCC) who underwent hepatectomy.

Methods: A propensity score matching analysis was conducted. Patients were categorized into two groups MetS-related hepatocellular carcinoma (MetS-HCC) and 1:1 matched non-MetS-related HCC (non-MetS-HCC). Surgical outcomes were compared between the two groups.

Results: Seventy-four MetS-HCC patients and 74 propensity score-matched non-MetS-HCC patients were selected for analysis. The incidence of surgical site infection was higher in the MetS-HCC group than in the non-MetS-HCC group (12.16% vs 0%, P < .005). There was no difference in the recurrence-free survival and overall survival between patients in the MetS-HCC group and in non-MetS-HCC group (P > .05). Microvascular invasion and severe postoperative complications were independent risk factors for recurrence-free survival and overall survival.

Conclusions: Hepatectomy for patients with mostly HBV-related HCC in the presence of MetS can result in a higher rate of postoperative surgical site infection compared with those in the absence of MetS, but long-term survival rates are comparable.

Keywords: hepatectomy; hepatocellular carcinoma; metabolic syndrome; survival.

Abstract

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